YjbH regulates virulence genes expression and oxidative stress resistance in <i>Staphylococcus aureus</i>

We previously reported that disruption of the yjbI gene reduced virulence Staphylococcus aureus. In this study, we found in both silkworms and mice was restored by introducing yjbH but not to genes-disrupted mutants, suggesting yjbH, downstream a two-gene operon-yjbIH, is responsible for phenomenon. further observed decrease various surface-associated proteins changes cell envelope glycostructures mutants. RNA-seq analysis revealed genes resulted differential expression broad range genes, notably, significant downregulation involved oxidative stress. Administration N-acetyl-L-cysteine, free-radical scavenger, Our findings suggested YjbH plays role staphylococcal pathogenicity regulating expression, affecting bacterial surface structure, conferring resistance stress host.